Antiallergic Activity of Prenylated Isoflavone from Cudrania tricuspidata in Antigen-Stimulated Mast Cells
- Antiallergic Activity of Prenylated Isoflavone from Cudrania tricuspidata in Antigen-Stimulated Mast Cells
- 김명석; 임수지; 노주원
- Cudrania tricuspidata; Prenylated isoflavone; IgE; Degranulation; RBL-2H3 cells
- Issue Date
- 대한면역학회 춘계학술대회
- Isoflavones are known to possess immunomodulating and antiallergic activities. Previously we identified prenylated isoflavone (6,8-diprenylorobol (DPO), 6,8-diprenylgenistein (DPG), 4'-O-methylalpinumisoflavone (MAI)) from Cudrania tricuspidata extract. The biological activity of prenylated isoflavone, however, remains unknown. In this study, DPO, DPG, and MAI showed the strongest inhibition of degranulation and histamine release. Additionally, the release and mRNA expression of interleukin (IL)-4 and tumor necrosis factor (TNF)-α was decreased by DPO, DPG, and MAI in antigen-stimulated RBL-2H3 cells. To elucidate the antiallergic mechanism of DPO, DPG, and MAI, we examined whether it affected levels of signaling molecules responsible for degranulation. The levels of activated JNK, ERK, and p38 proteins were reduced in DPO, DPG, and MAI treated RBL-2H3 cells. These results suggest that DPO, DPG, and MAI might be used as a therapeutic agent for allergic diseases.
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