Quantitative Analysis of Tryptophan and Its Metabolites from Plasma in Gastric Cancer Patients Using LC-MS/MS
- Quantitative Analysis of Tryptophan and Its Metabolites from Plasma in Gastric Cancer Patients Using LC-MS/MS
- 최종민; 이화정; 정병화
- Tryptophan; Metabolites; Gastric cancer; LC-MS/MS
- Issue Date
- Gastric cancer is one of the most common cancers in Korea and a significant cause of deaths worldwide as well. Indoleamine 2,3-dioxygenase (IDO), which is a rate-limiting enzyme in the catabolism of tryptophan, has been known to play a key role in gastric cancer immune suppression. It is noteworthy to investigate the changes of metabolites in tryptophan catabolism. Tryptophan is an essential amino acid. This amino acid and its metabolites are mostly biologically active and related to pathogenesis of various diseases. For the first step of overlooking metabolic pathway of tryptophan, the quantitative analysis of tryptophan and its metabolites (indole-3-lactic acid, anthranilic acid, serotonin, nicotinic acid, kynurenine, kynurenic acid and 3-indoxyl sulfate) was performed in this study from plasma of gastric cancer patients using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
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