Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A

Title
Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A
Authors
이수현강세미최만호이정애박미정김신혜이원용홍종기정봉철
Keywords
steroid; bisphenol A; precocious puberty; GC-MS; metabolite profiling; metabolomics; Gas chromatography-mass spectrometry
Issue Date
2014-04
Publisher
Reproductive toxicology
Citation
VOL 44, 1-6
Abstract
Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16α-hydroxy-dehydroepiandrosterone, and 5α-androstenedione tended to be high in both PP groups, and the level of 17β-estradiol was higher in the central-PP group (P < 0.01) than in the peripheral-PP and 32 age-matched healthy girls. Altered steroid metabolism was also associated with urinary BPA levels, and levels of testosterone, 17β-estradiol, and pregnenolone were significantly increased among individuals with high BPA levels. In particular, a correlation was observed between estrogen metabolism and BPA levels irrespective of the type of PP. These findings suggest that in girls, BPA exposure causes metabolic changes in steroidogenesis, but not the early onset of PP
URI
http://pubs.kist.re.kr/handle/201004/47515
ISSN
08906238
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KIST Publication > Article
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