Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A
- Changes in steroid metabolism among girls with precocious puberty may not be associated with urinary levels of bisphenol A
- 이수현; 강세미; 최만호; 이정애; 박미정; 김신혜; 이원용; 홍종기; 정봉철
- steroid; bisphenol A; precocious puberty; GC-MS; metabolite profiling; metabolomics; Gas chromatography-mass spectrometry
- Issue Date
- Reproductive toxicology
- VOL 44, 1-6
- Precocious puberty (PP) refers to the appearance of physical and hormonal signs of pubertal development at an abnormally early age. Urinary steroid signatures obtained from 42 patients with central PP and 40 patients with peripheral PP were assessed to compare metabolic changes. Levels of androgens such as testosterone, androstenedione, androstenediol, 16α-hydroxy-dehydroepiandrosterone, and 5α-androstenedione tended to be high in both PP groups, and the level of 17β-estradiol was higher in the central-PP group (P < 0.01) than in the peripheral-PP and 32 age-matched healthy girls. Altered steroid metabolism was also associated with urinary BPA levels, and levels of testosterone, 17β-estradiol, and pregnenolone were significantly increased among individuals with high BPA levels. In particular, a correlation was observed between estrogen metabolism and BPA levels irrespective of the type of PP. These findings suggest that in girls, BPA exposure causes metabolic changes in steroidogenesis, but not the early onset of PP
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