Inhibitory Effects of Paeonia anomala and Its Active Compound Gnetin H on Allergy-Related Mediator Production in Rat Basophilic Leukemia Mast Cells
- Inhibitory Effects of Paeonia anomala and Its Active Compound Gnetin H on Allergy-Related Mediator Production in Rat Basophilic Leukemia Mast Cells
- 김명석; 임수지; 노주원
- Paeonia anomala; Gnetin H; RBL-2H3; IgE; degranulation; histamine
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- Paeonia anomala is used in Mongolian traditional medicine for treating lower abdominal pain, kidney diseases, blood clotting, indigestion, nocturnal enuresis, hemorrhage, exhaustion, and respiratory tract disorders. However, effects of Paeonia anomala extract (PAE) on immunoglobulin (Ig) E-mediated allergic responses still remain elusive. In the present study, the effects of PAE and its active constituents on activation and degranulation of rat basophilic leukemia (RBL-2H3) mast cells were investigated. To evaluate the antiallergic effects of PAE and its active constituents, we determined its effects on degranulation, and inflammatory mediators in IgE-stimulated RBL-2H3 cells. PAE and Gnetin H inhibited secretion of β-hexosaminidase and histamine. PAE and Gnetin H reduced the production of prostaglandin E2, interleukin (IL)-4, and tumor necrosis factor (TNF)-α. Furthermore, PAE and Gnetin H attenuated phosphorylation of the mitogen-activated protein kinases extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase expression. These results indicate that PAE and its active compound Gnetin H might be useful as an agent against immediate-type hypersensitivity.
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