Chemical tumor-targeting of nanoparticles based on metabolic glycoengineering and click chemistry

Title
Chemical tumor-targeting of nanoparticles based on metabolic glycoengineering and click chemistry
Authors
이상민구희범나진희한승진민현수이소진김선화윤석현정서영권익찬최귀원김광명
Keywords
nanoparticle; click chemistry; metabolic glycoengineering; tumor targeting; drug delivery
Issue Date
2014-03
Publisher
ACS Nano
Citation
VOL 8, NO 3, 2048-2063
Abstract
Tumor-targeting strategies for nanoparticles have been predominantly based on optimization of physical properties or conjugation with biological ligands. However, their tumor-targeting abilities remain limited and insufficient. Furthermore, traditional biological binding molecules have intrinsic limitations originating from the limited amount of cellular receptors and the heterogeneity of tumor cells. Our two-step in vivo tumor-targeting strategy for nanoparticles is based on metabolic glycoengineering and click chemistry. First, an intravenous injection of precursor-loaded glycol chitosan nanoparticles generates azide groups on tumor tissue specifically by the enhanced permeation and retention (EPR) effect followed by metabolic glycoengineering. These ‘receptor-like’ chemical groups then enhance the tumor-targeting ability of drug-containing nanoparticles by copper-free click chemistry in vivo during a second intravenous injection. The advantage of this protocol over traditional binding molecules is that there are significantly more binding molecules on the surface of most tumor cells regardless of cell type. The subsequent enhanced tumor-targeting ability can significantly enhance the cancer therapeutic efficacy in animal studies.
URI
http://pubs.kist.re.kr/handle/201004/47531
ISSN
19360851
Appears in Collections:
KIST Publication > Article
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