A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells

Title
A glimpse into the interactions of cells in a microenvironment: the modulation of T cells by mesenchymal stem cells
Authors
Jonghoon Choi황민태이종욱이관희
Keywords
mesenchymal stem cell; T cell; microwell array
Issue Date
2014-05
Publisher
International journal of nanomedicine
Citation
VOL 9, NO Suppl 1, 127-139
Abstract
Mesenchymal stem cells (MSCs) have been thought to hold potential as a mode of therapy for immuno-related pathologies, particularly for autoimmune diseases. Despite their potential, the interaction between MSCs and T cells, key players in the pathophysiology of autoimmune diseases, is not yet well understood, thereby preventing further clinical progress. A major obstacle is the highly heterogeneous nature of MSCs in vitro. Unfortunately, bulk assays do not provide information with regard to cell–cell contributions that may play a critical role in the overall cellular response. To address these issues, we investigated the interaction between smaller subsets of MSCs and CD4 T cells in a microwell array. We demonstrate that MSCs appear capable of modulating the T cell proliferation rate in response to persistent cell–cell interactions, and we anticipate the use of our microwell array in the classification of subpopulations within MSCs, ultimately leading to specific therapeutic interventions.
URI
http://pubs.kist.re.kr/handle/201004/47547
ISSN
11782013
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KIST Publication > Article
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