Cytokine levels of the aqueous humour in central serous chorioretinopathy
- Cytokine levels of the aqueous humour in central serous chorioretinopathy
- 정상훈; 김경아; Sohn Sea Woon; Yang Sung Jae
- aqueous humour; bevacizumab; central serous chorioretinopathy; cytokines
- Issue Date
- Clinical and Experimental Optometry
- VOL 97, NO 3, 264-269
- Background: This study aimed to investigate the levels of aqueous humour cytokines in the
eyes of patients with central serous chorioretinopathy (CSC), who received an intravitreal
injection of bevacizumab, and to evaluate the differences in cytokine levels between
bevacizumab responders and non-responders.
Methods: Aqueous humour samples were collected from 39 eyes of 39 patients with CSC
and 25 eyes of 25 control patients undergoing cataract surgery and were analysed using
Multiplex bead assays. We compared the cytokine levels in patients with CSC (responders
and non-responders) and control subjects. After intravitreal injections of bevacizumab in
patients with CSC, we evaluated the changes in visual acuity and optical coherence tomographic parameters.
Results: Significantly increased levels of interferon gamma-induced protein (IP-10) were
detected in the aqueous humour of eyes from patients with CSC compared to controls
(p = 0.036). Vascular endothelial growth factor (VEGF) levels were significantly higher
in bevacizumab responders than in non-responders (p = 0.021). The concentrations of the
other cytokines investigated did not differ significantly between patients with CSC and
control subjects or between responders and non-responders.
Conclusion: The results of the present study suggest that IP-10 and VEGF may contribute
to the pathogenesis of CSC. It is clear that intravitreal bevacizumab was helpful in some of the
patients with CSC, who showed higher levels of VEGF in the aqueous humour. However, the
true effect and the rationale of anti-VEGF injection treatment in patients with CSC remain
to be elucidated. Our results suggest that patients with CSC may be more susceptible to VEGF
and/or other cytokines than the normal population.
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