Inhibitory Effects of Larix sibirica and Euphorbia pallasii on IgE-Mediated Mast Cell Activation
- Inhibitory Effects of Larix sibirica and Euphorbia pallasii on IgE-Mediated Mast Cell Activation
- 김명석; 임수지; 노주원
- Larix sibirica; Euphorbia pallasii; IgE; Degranulation; RBL-2H3
- Issue Date
- 생화학분자생물학회 (KSBMB)
- Immediate-type hypersensitivity is characterized by elevated levels of immunoglobulin E (IgE) and activated mast cell plays a crucial role by releasing granule contents, lipid-derived mediators, cytokines, and chemokines. To evaluate the antiallergic effects of Larix sibirica extract (LSE) and Euphorbia pallasii extract (EPE), we determined its effects on degranulation, and inflammatory mediators in IgE-stimulated rat basophilic leukemia cells. LSE and EPE inhibited secretion of β-hexosaminidase and histamine. LSE and EPE reduced the production of prostaglandin E2 and the mRNA expression of interleukin-4 and tumor necrosis factor-α. Furthermore, LSE and EPE attenuated phosphorylation of the mitogen-activated protein kinases (MAPK) extracellular signal-regulated kinase (ERK), p38, and c-Jun N-terminal kinase (JNK) expression. These results indicate that LSE and EPE might be useful as an agent against immediate-type hypersensitivity.
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