Fabrication of a Nanohybrid of Conjugated Polymer Nanoparticles and Graphene Oxide for Biosensing of Trypsin
- Fabrication of a Nanohybrid of Conjugated Polymer Nanoparticles and Graphene Oxide for Biosensing of Trypsin
- 노재국; 채병재; 구본철; 이택승
- sensors; fluorescence; conjugated polymer nanoparticles; trypsin; graphene oxide; conjugated polymers
- Issue Date
- Journal of polymer science Part A, Polymer chemistry
- VOL 52, NO 13, 1898-1904
- Conjugated polymers containing triphenylamine group are synthesized via Suzuki coupling polymerization. Fluorescent-conjugated polymer nanoparticles (CPN) are prepared by reprecipitation method using the newly synthesized conjugated polymer. CPN can be encapsulated with polyarginine by electrostatic interaction. The CPN modified with polyarginine exhibit excellent interaction with graphene oxide (GO) which is chemically modified with hydrophilic groups that possesses negative charge, which, in turn, induces the quenching of the fluorescence of CPN upon formation of CPN–GO nanohybrid. Upon exposure to trypsin, the quenched fluorescence is recovered by release of CPN from the nanohybrid, because trypsin cleaves the polyarginine linkage, resulting in weakening of interaction between CPN and GO.
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