Fabrication of a Nanohybrid of Conjugated Polymer Nanoparticles and Graphene Oxide for Biosensing of Trypsin

Title
Fabrication of a Nanohybrid of Conjugated Polymer Nanoparticles and Graphene Oxide for Biosensing of Trypsin
Authors
노재국채병재구본철이택승
Keywords
sensors; fluorescence; conjugated polymer nanoparticles; trypsin; graphene oxide; conjugated polymers
Issue Date
2014-07
Publisher
Journal of polymer science Part A, Polymer chemistry
Citation
VOL 52, NO 13, 1898-1904
Abstract
Conjugated polymers containing triphenylamine group are synthesized via Suzuki coupling polymerization. Fluorescent-conjugated polymer nanoparticles (CPN) are prepared by reprecipitation method using the newly synthesized conjugated polymer. CPN can be encapsulated with polyarginine by electrostatic interaction. The CPN modified with polyarginine exhibit excellent interaction with graphene oxide (GO) which is chemically modified with hydrophilic groups that possesses negative charge, which, in turn, induces the quenching of the fluorescence of CPN upon formation of CPN–GO nanohybrid. Upon exposure to trypsin, the quenched fluorescence is recovered by release of CPN from the nanohybrid, because trypsin cleaves the polyarginine linkage, resulting in weakening of interaction between CPN and GO.
URI
http://pubs.kist.re.kr/handle/201004/47631
ISSN
0887624X
Appears in Collections:
KIST Publication > Article
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