Anticarcinogenic Effects of Products of Heat-Processed Ginsenoside Re, a Major Constituent of Ginseng Berry, on Human Gastric Cancer Cells

Title
Anticarcinogenic Effects of Products of Heat-Processed Ginsenoside Re, a Major Constituent of Ginseng Berry, on Human Gastric Cancer Cells
Authors
장혁재한임호김영주Noriko Yamabe이다혜Gwi Seo Hwang오미영최경철김수남함정엽엄대운강기성
Keywords
ginsenoside Re; heat-processing; gastric cancer; cell cycle arrest; apoptosis
Issue Date
2014-04
Publisher
Journal of agricultural and food chemistry
Citation
VOL 62, NO 13, 2830-2836
Abstract
Ginsenoside Re is a triol type triterpene glycoside and is abundantly present in ginseng berry. In the present study, we verified that ginsenoside Re can be transformed into less-polar ginsenosides, namely, Rg2, Rg6, and F4, by heat-processing. The products of heat-processed ginsenoside Re inhibited phosphorylation of CDK2 at Thr160 by upregulation of p21 level, resulting in S phase arrest. The products of heat-processed ginsenoside Re also activated caspase-8, caspase-9, and caspase-3, followed by cleavage of PARP, a substrate of caspase-3, in a dose-dependent manner. Concurrently, alteration of mitochondrial factors such as Bcl-2 and Bax was also observed. Moreover, pretreatment with Z-VAD-fmk abrogated caspase-8, -9, and -3 activations by the products of heat-processed ginsenoside Re. We further confirmed that the anticancer effects of the products of heat-processed ginsenoside Re in AGS cells are mainly mediated via generation of less-polar ginsenosides Rg6 and F4.
URI
http://pubs.kist.re.kr/handle/201004/47644
ISSN
00218561
Appears in Collections:
KIST Publication > Article
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