Association between some endocrine-disrupting chemicals and childhood obesity in biological samples of young girls: A cross-sectional study

Title
Association between some endocrine-disrupting chemicals and childhood obesity in biological samples of young girls: A cross-sectional study
Authors
최재연엄진희김지예이상혁김연제
Keywords
endocrine-disrupting chemicals; childhood obesity; Phthalate; Alkylphenol; biological samples; Bisphenol A; young girls; Endogenous steroids; cross-sectional study
Issue Date
2014-07
Publisher
Environmental toxicology and pharmacology
Citation
VOL 38, NO 1, 51-57
Abstract
tChildhood obesity, a major public health concern, has increased worldwide. Endocrine-disrupting chemicals (EDCs) have recently received attention as a cause of obesity. Across-sectional study using logistic regression was conducted to investigate the associa-tion between some endocrine disrupting chemicals and obesity in young girls. Endogenoussteroids expected to be associated with EDCs were also investigated. The target compoundsincluded 7 phthalates (MEP, DBP, MBP, DEHP, MEHP, PA and MBzP), 2 alkylphenols (4-NP andt-OP), bisphenol A and 9 endogenous steroids (DHT, epi-T, T, DHEA, A, P, E1, E2 and E3). PA inurine and MEP, DBP and PA in serum showed statistically significant differences between thecontrol and obese groups, those compounds were considered to be associated with obesity.In addition, DHEA in serum showed a statistically significant difference between obese andcontrol groups. We concluded that these substances can affect the development of obesity.
URI
http://pubs.kist.re.kr/handle/201004/47683
ISSN
13826689
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KIST Publication > Article
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