Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach

Title
Identification of biomarkers for endometriosis in plasma from patients with endometriosis using a proteomics approach
Authors
황진희이규섭주종길왕타오손정빈박종하황대윤최만호이홍구
Keywords
endometriosis; haptoglobin; plasma; proteomics; biomarkers
Issue Date
2014-08
Publisher
Molecular Medicine Reports
Citation
VOL 10, NO 2, 725-730
Abstract
The present study aimed to examine potential biomarkers for the diagnosis of endometriosis. A plasma-based proteomic approach, including 2-dimentional electrophoresis and mass spectrometry, was used. Samples were obtained from patients with (n=15) and without (n=15) endometriosis, or from mice with surgically induced endometriosis. Seven spots corresponding to six differentially expressed proteins were identified in the human plasma samples. However, only haptoglobin (Hp) was identified to be significantly decreased in the plasma levels of patients with endometriosis (P<0.05) and in mice with surgically induced endometriosis (P<0.05). The results demonstrated that Hp was downregulated in females with endometriosis, and it therefore, may be a useful diagnostic tool as a biomarker of endometriosis.
URI
http://pubs.kist.re.kr/handle/201004/47722
ISSN
17912997
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KIST Publication > Article
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