Antibiral Properties of Silver Nanoparticles on a Magnetic Hybrid Colloid

Title
Antibiral Properties of Silver Nanoparticles on a Magnetic Hybrid Colloid
Authors
박성준박혜헌김성연김수정우경자고광표
Keywords
Antiviral; silver nanoparticle; magnetic hybrid colloid; pathogen; environment; bacteriophage
Issue Date
2014-04
Publisher
Applied and environmental microbiology
Citation
VOL 80, NO 8, 2343-2350
Abstract
Silver nanoparticles (AgNPs) are considered to be a potentially useful tool for controlling various pathogens. However, there are concerns about the release of AgNPs into environmental media, as they may generate adverse human health and ecological effects. In this study, we developed and evaluated a novel micrometer-sized magnetic hybrid colloid (MHC) decorated with variously sized AgNPs (AgNP-MHCs). After being applied for disinfection, these particles can be easily recovered from environmental media using their magnetic properties and remain effective for inactivating viral pathogens. We evaluated the efficacy of AgNP-MHCs for inactivating bacteriophage X174, murine norovirus (MNV), and adenovirus serotype 2 (AdV2). These target viruses were exposed to AgNP-MHCs for 1, 3, and 6 h at 25°C and then analyzed by plaque assay and real-time TaqMan PCR. The AgNP-MHCs were exposed to a wide range of pH levels and to tap and surface water to assess their antiviral effects under different environmental conditions. Among the three types of AgNP-MHCs tested, Ag30-MHCs displayed the highest efficacy for inactivating the viruses. The ΦX174 and MNV were reduced by more than 2 log10 after exposure to 4.6 109 Ag30-MHCs/ml for 1 h. These results indicated that the AgNP-MHCs could be used to inactivate viral pathogens with minimum chance of potential release into environment.
URI
http://pubs.kist.re.kr/handle/201004/47753
ISSN
00992240
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KIST Publication > Article
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