Identification and Biosynthesis of New Acyloins from the Thermophilic Bacterium Thermosporothrix hazakensis SK20-1T

Title
Identification and Biosynthesis of New Acyloins from the Thermophilic Bacterium Thermosporothrix hazakensis SK20-1T
Authors
박진수Noritaka KagayaJunko HashimotoMiho IzumikawaShuhei YabeKazuo Shin-yaMakoto NishiyamaTomohisa Kuzuyama
Keywords
biosynthesis; thermophlic bacteria; acyloins; enzymes; Thermosporothrix hazakensis
Issue Date
2014-03
Publisher
Chembiochem : a European journal of chemical biology
Citation
VOL 15, NO 4, 527-532
Abstract
Two new acyloin compounds were isolated from the thermophilic bacterium Thermosporothrix hazakensis SK20-1T. Genome sequencing of the bacterium and biochemical studies identified the thiamine diphosphate (TPP)-dependent enzyme Thzk0150, which is involved in the formation of acyloin. Through extensive analysis of the Thzk0150-catalyzed reaction products, we propose a putative reaction mechanism involving two substrates: 4-methyl-2-oxovalerate as an acyl donor and phenyl pyruvate as an acyl acceptor.
URI
http://pubs.kist.re.kr/handle/201004/47829
ISSN
14394227
Appears in Collections:
KIST Publication > Article
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