Identification and Biosynthesis of New Acyloins from the Thermophilic Bacterium Thermosporothrix hazakensis SK20-1T
- Identification and Biosynthesis of New Acyloins from the Thermophilic Bacterium Thermosporothrix hazakensis SK20-1T
- 박진수; Noritaka Kagaya; Junko Hashimoto; Miho Izumikawa; Shuhei Yabe; Kazuo Shin-ya; Makoto Nishiyama; Tomohisa Kuzuyama
- biosynthesis; thermophlic bacteria; acyloins; enzymes; Thermosporothrix hazakensis
- Issue Date
- Chembiochem : a European journal of chemical biology
- VOL 15, NO 4, 527-532
- Two new acyloin compounds were isolated from the thermophilic bacterium Thermosporothrix hazakensis SK20-1T. Genome sequencing of the bacterium and biochemical studies identified
the thiamine diphosphate (TPP)-dependent enzyme Thzk0150, which is involved in the formation of acyloin. Through extensive analysis of the Thzk0150-catalyzed reaction products, we propose a putative reaction mechanism involving two substrates: 4-methyl-2-oxovalerate as an acyl donor and phenyl pyruvate as an acyl acceptor.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.