Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors

Title
Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors
Authors
윤준한민수송치만천승훈최기항한호규
Keywords
anti depressant; depression; Antidepressant; Triple reuptake inhibitor; azetidine; 3-Phenethylazetidines
Issue Date
2014-08
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 24, NO 15, 3234-3237
Abstract
We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reuptake inhibitor with good selectivity as a candidate for depression.
URI
http://pubs.kist.re.kr/handle/201004/47837
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
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