KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model

Title
KHG26792 Inhibits Melanin Synthesis in Mel-Ab Cells and a Skin Equivalent Model
Authors
Li Hailan김잔디한호규윤준정효순윤혜영백광진권륜수민영실박경찬김동석
Keywords
ERK; KHG26792; Melanogenesis; Skin equivalent; Tyrosinase
Issue Date
2014-06
Publisher
The Korean Journal of Physiology & Pharmacology
Citation
VOL 18, NO 3, 249-254
Abstract
The purpose of this study is to characterize the effects of KHG26792 (3-(naphthalen-2-yl(propoxy) methyl)azetidine hydrochloride), a potential skin whitening agent, on melanin synthesis and identify the underlying mechanism of action. Our data showed that KHG26792 significantly reduced melanin synthesis in a dose-dependent manner. Additionally, KHG26792 downregulated microphthalmiaassociated transcription factor (MITF) and tyrosinase, the rate-limiting enzyme in melanogenesis, although tyrosinase was not inhibited directly. KHG26792 activated extracellular signal-regulated kinase (ERK), whereas an ERK pathway inhibitor, PD98059, rescued KHG26792-induced hypopigmentation. These results suggest that KHG26792 decreases melanin production via ERK activation. Moreover, the hypopigmentary effects of KHG26792 were confirmed in a pigmented skin equivalent model using Cervi cornus Colla (deer antler glue), in which the color of the pigmented artificial skin became lighter after treatment with KHG26792. In summary, our findings suggest that KHG26792 is a novel skin whitening agent.
URI
http://pubs.kist.re.kr/handle/201004/47839
ISSN
12264512
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KIST Publication > Article
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