Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)

Title
Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [11C]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)
Authors
김지영손명희최기항백두종고민경임은정배애님금교창이재균조용서추현아이윤우문병석이병철이호영민선준
Keywords
MPEQ; metabotropic glutamate receptor 5 (mGluR5); in vivo; PET imaging; Neuropathic pain
Issue Date
2014-08
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 35, NO 8, 2304-2310
Abstract
The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [11C]MPEQ 3 proved that accumulation of [11C]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.
URI
http://pubs.kist.re.kr/handle/201004/48259
ISSN
02532964
Appears in Collections:
KIST Publication > Article
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