Succinate production from CO2-grown microalgal biomass as carbon source using engineered C. glutamicum through consolidated bioprocessing

Title
Succinate production from CO2-grown microalgal biomass as carbon source using engineered C. glutamicum through consolidated bioprocessing
Authors
이정석엄영순오민규우한민
Issue Date
2014-10
Publisher
2014 한국생물공학회 추계학술발표대회 및 국제심포지엄
Abstract
This study presents the development of consolidated bioprocessing for succinate production from microalgal biomass using engineered Corynebacterium glutamicum. C. glutamicum is a widely-known industrial bacterium for producing amino acid and varieties of biochemical. C. glutamicum wild type is able to utilize glucose but not able to utilize starch as sole carbon source. Starch-degrading and succinate-producing C. glutamicum strains produced succinate (0.16 g succinate/g total carbon source) from a mixture of starch and glucose as a model microalgal biomass. Subsequently, the engineered C. glutamicum strains were able to produce succinate (0.28 g succinate/g of total sugars) from pretreated microalgal biomass of CO2-grown Chlamydomonas reinhardtii. For the first time, this work shows succinate production from CO2 via sequential fermentations of CO2-grown microalgae and engineered C. glutamicum. Therefore, consolidated bioprocessing based on microalgal biomass could be useful to promote variety of biorefineries. This work was supported by Korea CCS R&D Center (KCRC).
URI
http://pubs.kist.re.kr/handle/201004/48308
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KIST Publication > Conference Paper
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