Bistorta alopecuroides Attenuates Diet-induced Obesity and Steatosis by Activating AMP-activated Protein Kinase and Regulating Lipid Metabolism Cells

Title
Bistorta alopecuroides Attenuates Diet-induced Obesity and Steatosis by Activating AMP-activated Protein Kinase and Regulating Lipid Metabolism Cells
Authors
김명석임수지안홍열목일균정상훈노주원
Keywords
Bistorta alopecuroides; Obesity; Steatosis; AMPK; C57BL/6J; HepG2
Issue Date
2014-08
Publisher
한국식품과학회
Citation
, 157-157
Abstract
The medicinal plant Bistorta alopecuroides has been reported to possess anti-oxidative and anti-inflammatory properties; however, its anti-obesity activity is unexplored. The present study was conducted to determine whether B. alopecuroides extract (BAE), prepared from its rhizome parts, attenuated high-fat diet (HFD)-induced obesity in C57BL/6J mice. The molecular mechanism was investigated in HepG2 human hepatoma cells. BPE treatment decreased lipid and triglyceride accumulation in HepG2 hepatocytes by activating AMP-activated protein kinase (AMPK) signaling and regulating the expression of lipid metabolism-related proteins. In the animal model, oral administration of BAE (200 mg/kg/day for 8 weeks) significantly reduced HFD-induced body weight gain without altering the amount of food intake. Fat pad masses were reduced in BAE-treated mice, as evidenced by reduced adipocyte size. Furthermore, BAE protected against the development of nonalcoholic fatty liver by decreasing hepatic triglyceride accumulation. Taken together, these findings indicate that BAE attenuates HFD-induced obesity by activating AMPK and regulating lipid metabolism, suggesting a potent anti-obesity agent.
URI
http://pubs.kist.re.kr/handle/201004/48310
Appears in Collections:
KIST Publication > Conference Paper
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