Naturomimetic Approach Method를 이용한 생리활성 아릴나프탈렌락톤 리그난 천연물의 SAR 연구 1

Title
Naturomimetic Approach Method를 이용한 생리활성 아릴나프탈렌락톤 리그난 천연물의 SAR 연구 1
Authors
김태정정규혁최필주김영석김관태함정엽
Keywords
아릴나프탈렌락톤; 리그난; 천연물 유도체; 유기합성
Issue Date
2014-10
Publisher
대한화학회 추계 학술대회
Abstract
Biaryl compounds are an important class of substances, not only as structures found in a variety of natural products, but also as a chiral source for asymmetric synthesis. A biaryl skeleton such as A in usually constructed through an aryl-aryl coupling reaction between two aromatic compounds such as B and C. On the other hand, arylnaphthalene lactone lignans occur widely in nature and exhibit various biological activities. If this type coupling reaction were to proceed between sulfonate B (derived from precursor D) and boron aryl compound C, various arylnaphthalene lactone derivatives A would be synthesized in a few steps involving a Hauser-Kraus annulation. Those arylnaphthalene lactone derivatives should be key intermediates for the syntheses of Diphyllin, Justicidins, Taiwanin, etc. Herein we report the total synthesis of 12 arylnaphthalene lactone lignans by using a Hauser-Kraus annulation and Naturomimetic approach (aryl-aryl coupling)as key steps.
URI
http://pubs.kist.re.kr/handle/201004/48365
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KIST Publication > Conference Paper
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