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|dc.description.abstract||Biaryl compounds are an important class of substances, not only as structures found in a variety of natural products, but also as a chiral source for asymmetric synthesis. A biaryl skeleton such as A in usually constructed through an aryl-aryl coupling reaction between two aromatic compounds such as B and C. On the other hand, arylnaphthalene lactone lignans occur widely in nature and exhibit various biological activities. If this type coupling reaction were to proceed between sulfonate B (derived from precursor D) and boron aryl compound C, various arylnaphthalene lactone derivatives A would be synthesized in a few steps involving a Hauser-Kraus annulation. Those arylnaphthalene lactone derivatives should be key intermediates for the syntheses of Diphyllin, Justicidins, Taiwanin, etc. Herein we report the total synthesis of 12 arylnaphthalene lactone lignans by using a Hauser-Kraus annulation and Naturomimetic approach (aryl-aryl coupling)as key steps.||-|
|dc.publisher||대한화학회 추계 학술대회||-|
|dc.title||Naturomimetic Approach Method를 이용한 생리활성 아릴나프탈렌락톤 리그난 천연물의 SAR 연구 1||-|
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