Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model

Title
Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model
Authors
조수민김현진이세진김혜연김웅김태송김동진김영수
Keywords
치매; 알츠하이머병; 진단; 혈액; dementia; Alzheimer; diagnosis; blood; 개방형연구사업; ORP
Issue Date
2014-10
Publisher
Scientific Reports
Citation
VOL 4, 6777-1-6777-4
Abstract
Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of Alzheimer’s disease (AD), the link between the alternation of Ab level in the blood and the progress of the disorder is still controversial. Here, we report a direct correlation of Aβ(1–42) levels between CSF and plasma in AD mouse model. We injected monomeric Aβ(1–42) directly into the intracerebroventricular (ICV) region of normal adult mouse brains to induce AD-like phenotypes. Using sandwich enzyme-linked immunosorbent assays, we observed proportional elevation of Aβ(1–42) levels in both CSF and plasma in a dose-dependent manner. Our findings that plasma Aβ(1–42) reflects the condition of CSF Aβ(1–42) warrant further investigation as a biomarker for the blood diagnosis of AD.
URI
http://pubs.kist.re.kr/handle/201004/48448
ISSN
20452322
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KIST Publication > Article
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