Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk

Title
Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk
Authors
Hae Jong KimKyeoung-Hwa KimJaehyouk LeeJong Jin OhHyun Sub Cheong이 린 웡양범석Seok Soo ByunSoon Chul Myung
Keywords
FGF23; polymorphism; prostate cancer
Issue Date
2014-08
Publisher
BJU international
Citation
VOL 114, NO 2, 303-310
Abstract
Objective To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population. Patients and Methods Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia.Single‐locus analyses were conducted using conditional logistic regression.In addition, we performed a haplotype analysis for the five FGF23 SNPs tested. Results Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population.Odds ratios for homozygous variants vs wild‐type variants ranged from 1.68 (95% confidence interval [CI]: 1.15–2.46) to 1.79 (95% CI: 1.16–2.75). Conclusion This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.
URI
http://pubs.kist.re.kr/handle/201004/48551
ISSN
14644096
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KIST Publication > Article
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