Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk
- Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk
- Hae Jong Kim; Kyeoung-Hwa Kim; Jaehyouk Lee; Jong Jin Oh; Hyun Sub Cheong; 이 린 웡; 양범석; Seok Soo Byun; Soon Chul Myung
- FGF23; polymorphism; prostate cancer
- Issue Date
- BJU international
- VOL 114, NO 2, 303-310
To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population.
Patients and Methods
Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia.Single‐locus analyses were conducted using conditional logistic regression.In addition, we performed a haplotype analysis for the five FGF23 SNPs tested.
Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population.Odds ratios for homozygous variants vs wild‐type variants ranged from 1.68 (95% confidence interval [CI]: 1.15–2.46) to 1.79 (95% CI: 1.16–2.75).
This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.