Cardiomyocyte Contractile Force Changes in Response to Chemical Environments

Title
Cardiomyocyte Contractile Force Changes in Response to Chemical Environments
Authors
유진문효원이부용진주영장지은서준교박정열황유식김진석
Keywords
cardiomyocyte sensor; cardiac contraction force; PDMS cantileve
Issue Date
2014-04
Publisher
9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems
Abstract
In this study, we demonstrate that drug treatments change cardiomyocyte contractile force in vitro. Contractile force was determined by bending deflection of the cantilever end. We quantified the effect of Digoxin, Isoproterenol, and BayK8644, drugs that increase contractile force, on cardiomyocyte contractile forces when grown on the grooved cantilever. We also investigated the effect of Verapamil, which decreases contractile force. We applied Digoxin, Isoproterenol, and BayK8644 on day 8, and Verapamil on day 5. Digoxin, Isoproterenol, and BayK8644 increased cardiomyocyte contractile forces by 19.31%, 9.75%, and 23.81%, respectively. Verapamil decreased the contractile force by 48.06%. In summary, we monitored bending movement with cantilever sensors and concluded that cardiomyocyte contractile force changes in response to various drug treatments.
URI
http://pubs.kist.re.kr/handle/201004/48563
Appears in Collections:
KIST Publication > Conference Paper
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