Characterization of curcumin-loaded nanoparticles composed of phosphatidylcholine and β-cyclodextrin
- Characterization of curcumin-loaded nanoparticles composed of phosphatidylcholine and β-cyclodextrin
- 구송이; 김다혜; 판철호
- curcumin; nanoparticles
- Issue Date
- Curcumin, a dietary polyphenol derived from turmeric, has been widely used as a traditional medicine in many Asian counties, since it was reported that curcumin has antioxidant, anti-inflammatory, and anticancer properties. Although curcumin has numerous advantages, the application of curcumin is limited because of its poor solubility and bioavailability. In this study, curcumin-nanoparticles were fabricated by ethanol injection method using lecithin and inclusion complex method using β-cyclodextrin. In this study, we have developed curcumin-nanoparticles system and their physicochemical properties were compared with chitosan-coated curcumin nanoliposomes(CS-Cur-NLs), curcumin nanoliposome(Cur-NLs) and β-cyclodextrin-curcumin liposomal nanoparticles(CD-CUR). The mean size and zeta potential was investigated. The encapsulation efficiency of CS-Cur-NLs, Cur-NLs and CD-CUR was 58%, 75% and 80%, respectively. The mucoadhesive properties of curcumin-nanoparticles were characterized by measuring their mucin adsorption. The surface morphology was characterized by SEM. The results indicate the encapsulated curcumin will show prolonged adsorption in the gastrointestinal tract because of higher mucoadhesion. CS-Cur-NLs showed higher bioavailability, with enhanced high mucoadhesive property, storage stability, and encapsulation efficiency.
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