Characterization of curcumin-loaded nanoparticles composed of phosphatidylcholine and β-cyclodextrin

Title
Characterization of curcumin-loaded nanoparticles composed of phosphatidylcholine and β-cyclodextrin
Authors
구송이김다혜판철호
Keywords
curcumin; nanoparticles
Issue Date
2014-08
Publisher
한국식품과학회지
Abstract
Curcumin, a dietary polyphenol derived from turmeric, has been widely used as a traditional medicine in many Asian counties, since it was reported that curcumin has antioxidant, anti-inflammatory, and anticancer properties. Although curcumin has numerous advantages, the application of curcumin is limited because of its poor solubility and bioavailability. In this study, curcumin-nanoparticles were fabricated by ethanol injection method using lecithin and inclusion complex method using β-cyclodextrin. In this study, we have developed curcumin-nanoparticles system and their physicochemical properties were compared with chitosan-coated curcumin nanoliposomes(CS-Cur-NLs), curcumin nanoliposome(Cur-NLs) and β-cyclodextrin-curcumin liposomal nanoparticles(CD-CUR). The mean size and zeta potential was investigated. The encapsulation efficiency of CS-Cur-NLs, Cur-NLs and CD-CUR was 58%, 75% and 80%, respectively. The mucoadhesive properties of curcumin-nanoparticles were characterized by measuring their mucin adsorption. The surface morphology was characterized by SEM. The results indicate the encapsulated curcumin will show prolonged adsorption in the gastrointestinal tract because of higher mucoadhesion. CS-Cur-NLs showed higher bioavailability, with enhanced high mucoadhesive property, storage stability, and encapsulation efficiency.
URI
http://pubs.kist.re.kr/handle/201004/48633
ISSN
03676293
Appears in Collections:
KIST Publication > Conference Paper
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