A Concise Synthesis of Mupirocin H Using a Cross-Metathesis-Based Strategy

Title
A Concise Synthesis of Mupirocin H Using a Cross-Metathesis-Based Strategy
Authors
Sandip Sengupta심태보
Keywords
Mupirocin H; natural products; total synthesis; Polyketides; Metathesis; Reformatsky reaction
Issue Date
2014-08
Publisher
European journal of organic chemistry
Citation
VOL 2014, NO 23, 5063-5070
Abstract
A highly efficient (10.1 % overall yield) and convergent (longest linear sequence of 16 steps) synthesis of mupirocin H has been achieved, starting from commercially available (+)-(R)-Roche ester. The route relies on an efficient Grubbs cross-metathesis reaction to generate a key, late-stage E-olefin intermediate, and a cobalt-catalysed diastereoselective Reformatsky reaction to produce a β-hydroxy ester that serves as a late-stage intermediate.
URI
http://pubs.kist.re.kr/handle/201004/48647
ISSN
1434193X
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KIST Publication > Article
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