Engineered collagen hydrogels for the sustained release of biomolecules and imaging agents: promoting the growth of human gingival cells

Title
Engineered collagen hydrogels for the sustained release of biomolecules and imaging agents: promoting the growth of human gingival cells
Authors
Jonghoon Choi박호영Taeho KimYoon JeongMyoung Hwan Oh현택환Assaf A Gilad이관희
Keywords
engineered collagen hydrogels; imaging agents; sustained release; human gingival cells; biomolecules; growth
Issue Date
2014-11
Publisher
International journal of nanomedicine
Citation
VOL 9, NO 1, 5189-5201
Abstract
We present here the in vitro release profiles of either fluorescently labeled biomolecules or computed tomography contrast nanoagents from engineered collagen hydrogels under physiological conditions. The collagen constructs were designed as potential biocompatible inserts into wounded human gingiva. The collagen hydrogels were fabricated under a variety of conditions in order to optimize the release profile of biomolecules and nanoparticles for the desired duration and amount. The collagen constructs containing biomolecules/nanoconstructs were incubated under physiological conditions (ie, 37°C and 5% CO2) for 24 hours, and the release profile was tuned from 20% to 70% of initially loaded materials by varying the gelation conditions of the collagen constructs. The amounts of released biomolecules and nanoparticles were quantified respectively by measuring the intensity of fluorescence and X-ray scattering. The collagen hydrogel we fabricated may serve as an efficient platform for the controlled release of biomolecules and imaging agents in human gingiva to facilitate the regeneration of oral tissues.
URI
http://pubs.kist.re.kr/handle/201004/48668
ISSN
11782013
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KIST Publication > Article
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