Bioavailability of Ginsenosides from White and Red Ginsengs in the Simulated Digestion Model

Title
Bioavailability of Ginsenosides from White and Red Ginsengs in the Simulated Digestion Model
Authors
김은옥차광현이은하김상민최상원판철호엄병헌
Keywords
white ginseng; red ginseng; bioavailability; digestive stability; ginsenosides; simulated digestion; white and red ginsengs
Issue Date
2014-10
Publisher
Journal of agricultural and food chemistry
Citation
VOL 62, NO 41, 10055-10063
Abstract
This study aims to investigate the bioavailability of ginsenosides during simulated digestion of white (WG) and red (RG) ginseng powders. Stability, bioaccessibility, and permeability of ginsenosides present in WG and RG were studied in a Caco-2 cell culture model coupled with oral, gastric, and small intestinal simulated digestion. Most ginsenosides in WG and RG were stable (>90%) during the simulated digestion. Bioaccessibilities of total ginsenosides during in vitro digestion of WG and RG were similar at approximately 85%. However, the bioaccessibility of protopanaxatriol type ginsenosides in the early food phase was greater than that of the protopanaxadiol type. The less polar RG ginsenosides were released later following the jejunum phase. Ginsenosides had low permeability (<1 × 10&#8722;6 cm/s) through Caco-2 cell monolayers. These findings suggest that the WG and RG ginsenoside compositions affect bioaccessibility during digestion and that ginsenosides are poorly absorbed in humans.
URI
http://pubs.kist.re.kr/handle/201004/48680
ISSN
00218561
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KIST Publication > Article
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