Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
- Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
- Park, Joonyoung; Brust, Tarsis F.; Lee, Hong Jae; Lee, Sang Cheon; Watts, Val J.; 여윤
- polymeric nanoparticles; drug delivery; surface modification; dopamine polymerization; cell-nanoparticle interactions
- Issue Date
- ACS Nano
- VOL 8, NO 4, 3347-3356
- The surface of a polymeric nanoparticle (NP) is often functionalized
with cell-interactive ligands and/or additional polymeric layers to control NP
interaction with cells and proteins. However, such modification is not always
straightforward when the surface is not chemically reactive. For this reason, most
NP functionalization processes employ reactive linkers or coupling agents or involve
prefunctionalization of the polymer, which are complicated and inefficient.
Moreover, prefunctionalized polymers can lose the ability to encapsulate and
retain a drug if the added ligands change the chemical properties of the polymer.
To overcome this challenge, we use dopamine polymerization as a way of
functionalizing NP surfaces. This method includes brief incubation of the preformed
NPs in a weak alkaline solution of dopamine, followed by secondary incubation
with desired ligands. Using this method, we have functionalized poly(lactic-co-glycolic acid) (PLGA) NPs with three representative surface modifiers: a small molecule (folate), a peptide (Arg-Gly-Asp), and a polymer [poly(carboxybetaine methacrylate)]. We confirmed that the modified NPs showed the expected cellular interactions with no cytotoxicity or residual bioactivity of dopamine. The dopamine polymerization method is a simple and versatile surface modification method, applicable to a variety of NP drug carriers irrespective of their chemical reactivity and the types of ligands.
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