Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy
- Tumor-targeting glycol chitosan nanoparticles as a platform delivery carrier in cancer diagnosis and therapy
- 이소진; 민현수; 구숙희; 손소희; 권익찬; 김선화; 김광명
- EPR; amphiphilic nanoparticles; cancer therapy; diagnosis; glycol chitosan
- Issue Date
- VOL 9, NO 11, 1697-1713
- A natural based polymer, chitosan has received widespread attention in drug delivery systems due to its valuable physicochemical and biological characteristics. In particular, hydrophobic moiety-conjugated glycol chitosan can form amphiphilic self-assembled glycol chitosan nanoparticles (GCNPs) and simultaneously encapsulate hydrophobic drug molecules inside their hydrophobic core. This GCNP-based drug delivery systems exhibit excellent tumor-homing efficacy, attributed to the long blood circulation and the enhanced permeability and retention effect; this tumor-targeting drug delivery results in improved therapeutic efficiency. In this review, we describe the requisite properties of GCNPs for cancer therapy as well as imaging for diagnosis, such as their basic characteristics, in vitro delivery efficiency and in vivo tumor-targeting ability.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.