Complex adaptive therapeutic strategy (CATS) for cancer
- Complex adaptive therapeutic strategy (CATS) for cancer
- YongWoo Cho; 김상윤; 권익찬; 김인산
- Tumor heterogeneity; Complex adaptive system (CAS); Induced phenotype; Tumor network; Cancer immunotherapy; Nanoparticle
- Issue Date
- Journal of controlled release
- VOL 175, NO 10, 43-47
- Tumors begin with a single cell, but as each tumor grows and evolves, it becomes a wide collection of clones that display remarkable heterogeneity in phenotypic features, which has posed a big challenge to current targeted anticancer therapy. Intra- and inter-tumoral heterogeneity is attributable in part to genetic mutations but also to adaptation and evolution of tumors to heterogeneity in tumor microenvironments. If tumors are viewed not only as a disease but also as a complex adaptive system (CAS), tumors should be treated as such and a more systemic approach is needed. Some of many tumors therapeutic strategies are discussed here from a view of a tumor as CAS, which can be collectively called a complex adaptive therapeutic strategy (CATS). The central theme of CATS is based on three intermediate concepts: i) disruption of artifacts, ii) disruption of connections, and iii) reprogramming of cancer-immune dynamics. Each strategy presented here is a piece of the puzzle for CATS. Although each piece by itself may be neither novel nor profound, an assembled puzzle could be a novel and innovative cancer therapeutic strategy.
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