Theranostic nanomaterials for image-guided gene therapy

Title
Theranostic nanomaterials for image-guided gene therapy
Authors
황승림구숙희주민경김선화권익찬
Keywords
biomedical; biomaterial; nanoscale
Issue Date
2014-01
Publisher
MRS bulletin
Citation
VOL 39, NO 1, 44-50
Abstract
Theranostics was proposed as a combined process of therapeutics and diagnostics methodology for increasing treatment effi cacy and safety with simultaneous monitoring of the response to treatment. In the past two decades, nanotechnology has been the focus of developing strategies for drug delivery and imaging functions, and it has expanded to the design of multifunctional nanoparticles and the creation of “nanotheranostics” (i.e., theranostic nanomedicines). Nanotheranostics also shows potential in gene therapy; however, nanoparticle-mediated delivery of genes still faces major obstacles related to (1) theuptake by the reticuloendothelial system, (2) the ability to get across the target cell membranes through endocytosis, and (3) the ability to accumulate in organs with permeable vasculature. Here, we review the development and application of nanotheranostics, highlighting their relevance to gene therapy as well as molecular imaging.
URI
http://pubs.kist.re.kr/handle/201004/48695
ISSN
08837694
Appears in Collections:
KIST Publication > ETC
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