Targetable micelleplex hydrogel for long-term, effective, and systemic siRNA delivery

Title
Targetable micelleplex hydrogel for long-term, effective, and systemic siRNA delivery
Authors
김영민송수창
Keywords
Gene therapy; Nanoparticle; Hydrogel; Drug delivery
Issue Date
2014-09
Publisher
Biomaterials
Citation
VOL 35, NO 27, 7970-7977
Abstract
We developed a targetable micelleplex hydrogel as a new efficient systemic siRNA delivery material that functions as a targetable gene carrier, and a hydrogel capable of controlled release to overcome drawbacks of multiple administrations of systemic siRNA carriers due to decreased fluctuation of them in the serum. The micelleplexes, complexes between polymeric micelles and siRNAs could turn into gel after subcutaneous injection and be slowly released from the gel. The released micelleplexes selectively accumulated in the tumor and showed anti-tumor effect due to gene silencing for an extended period of time with only one injection in anywhere in vivo model. Moreover, the duration of therapy can be controlled by adjusting the amount and properties of the hydrogel. Therefore, this micelleplex hydrogel is expected to be a new effective siRNA delivery material for systemic long-term gene silencing.
URI
http://pubs.kist.re.kr/handle/201004/48769
ISSN
01429612
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE