Medicines for the Mind: Policy-Based "Pull" Incentives for Creating Breakthrough CNS Drugs

Title
Medicines for the Mind: Policy-Based "Pull" Incentives for Creating Breakthrough CNS Drugs
Authors
데니스최Robert ArmitageLinda S. BradyTimothy CoetzeeWilliam FisherSteven HymanAtul PandeSteven PaulWilliam PotterBenjamin RoinTodd Sherer
Keywords
brain diseases; translational; Medicine; nervous; CNS Drug; therapeutic; pharmaceutical company; policy; neuroscience; breakthrough drug
Issue Date
2014-11
Publisher
Neuron
Citation
VOL 84, NO 3, 554-563
Abstract
Several large pharmaceutical companies have selectively downsized their neuroscience research divisions, reflecting a growing view that developing drugs to treat brain diseases is more difficult and often more time-consuming and expensive than developing drugs for other therapeutic areas, and thus represents a weak area for investment. These withdrawals reduce global neuroscience translational capabilities and pose a serious challenge to society’s interests in ameliorating the impact of nervous system diseases. While the path forward ultimately lies in improving understandings of disease mechanisms, many promising therapeutic approaches have already been identified, and rebalancing the underlying risk/reward calculus could help keep companies engaged in making CNS drugs. One way to do this that would not require upfront funding is to change the policies that regulate market returns for the most-needed breakthrough drugs. The broader neuroscience community including clinicians and patients should convene to develop and advocate for such policy changes.
URI
http://pubs.kist.re.kr/handle/201004/48780
ISSN
08966273
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KIST Publication > Article
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