A capacitive biosensor based on an interdigitated electrode with nanoislands

Title
A capacitive biosensor based on an interdigitated electrode with nanoislands
Authors
Ha-Wook JungYoung Wook ChangGa-yeon LeeSungbo Cho강민정Jae-Chul Pyun
Keywords
capacitive biosensor; Interdigitated Electrode; Nanoislands; Hepatitis B virus; Surface antigen; Immunosensor
Issue Date
2014-09
Publisher
Analytica chimica acta
Citation
VOL 844, 27-34
Abstract
A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.
URI
http://pubs.kist.re.kr/handle/201004/48787
ISSN
00032670
Appears in Collections:
KIST Publication > Article
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