A capacitive biosensor based on an interdigitated electrode with nanoislands
- A capacitive biosensor based on an interdigitated electrode with nanoislands
- Ha-Wook Jung; Young Wook Chang; Ga-yeon Lee; Sungbo Cho; 강민정; Jae-Chul Pyun
- capacitive biosensor; Interdigitated Electrode; Nanoislands; Hepatitis B virus; Surface antigen; Immunosensor
- Issue Date
- Analytica chimica acta
- VOL 844, 27-34
- A capacitive biosensor based on an interdigitated electrode (IDE) with nanoislands was developed for label-free detection of antigen-antibody interactions. To enable sensitive capacitive detection of protein adsorption, the nanoislands were fabricated between finger electrodes of the IDE. The effect of the nanoislands on the sensitive capacitive measurement was estimated using horseradish peroxidase (HRP) as a model protein. Additionally, a parylene-A film was coated on the IDE with nanoislands to improve the efficiency of protein immobilization. By using HRP and hepatitis B virus surface antigen (HBsAg) as model analytes, the effect of the parylene-A film on the capacitive detection of protein adsorption was demonstrated.
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