Cell-based Models To Investigate Tau Aggregation

Title
Cell-based Models To Investigate Tau Aggregation
Authors
임성수마무눌 하크김도희김동진김윤경
Keywords
Tauopathy; Tau phosphorylation; Tau oligomerization; Tau aggregation; In vitro assay; Cell-based sensor; BiFC
Issue Date
2014-11
Publisher
Computational and Structural Biotechnology Journal
Citation
VOL 12, NO 20-21, 7-13
Abstract
Accumulation of abnormal tau aggregates in neuron is an important pathological signature in multiple neurodegenerative disorders including Alzheimer's disease. Tau is a neuron specific microtubule-associated protein that regulates microtubule stability, which is critical for axonal outgrowth and synaptic plasticity. In a pathological condition, tau dissociates from microtubules and forms insoluble aggregates called neurofibrillary tangles (NFTs). The accumulation of NFTs in neuron directly correlates with microtubule dysfunction and neuronal degeneration. Due to the pathophysiological importance of tau, great efforts have been made to understand tau aggregation processes and find therapeutics to halt or reverse the processes. However, progress has been slow due to the lack of a suitable method for monitoring tau aggregation. In this mini-review, we will review the conventional methods for studying tau aggregation, and introduce recent cell-based sensor approaches that allow monitoring tau aggregation in living cells.
URI
http://pubs.kist.re.kr/handle/201004/48843
ISSN
20010370
Appears in Collections:
KIST Publication > ETC
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