Preparation of lotus-leaf-like structured blood compatible poly(ε-caprolactone)-block-poly(l-lactic acid) copolymer film surfaces
- Title
- Preparation of lotus-leaf-like structured blood compatible poly(ε-caprolactone)-block-poly(l-lactic acid) copolymer film surfaces
- Authors
- 김승일; 임진익; 이보람; Cho Hay Mun; 정영미; 김수현
- Keywords
- PCL-b-PLLA; Surface modification; Lotus-leaf-like; Blood compatibility; Cell proliferationa
- Issue Date
- 2014-02
- Publisher
- Colloids and surfaces. B, Biointerfaces
- Citation
- VOL 114, 28-35
- Abstract
- Lotus-leaf-like structured poly( -caprolactone)-block-poly(l-lactic acid) copolymer (PCL-b-PLLA) filmscast using the solvent–nonsolvent casting method. PCL-b-PLLA was synthesized by the well-knowncopolymerization process, and was confirmed by1H NMR analysis. The molecular weight of the syn-thesized PCL-b-PLLA was measured by gel permeation chromatography (GPC). The number-average(Mn), weight-average (Mw) molecular weights and polydispersity (Mw/Mn) were 3.9 × 104, 5.1 × 104,and 1.3, respectively. PCL-b-PLLA films were cast in vacuum conditions with various nonsolvent ratios.Tetrahydrofuran (THF) was used as solvent and ethanol was used as nonsolvent. Surface hydrophobic-ity was confirmed by the water contact angle. The water contact angle was increased from 90.9◦± 4.2◦to 130.2◦± 3.6◦. Water contact angle was found to be influenced by surface topography. The preparedfilm surfaces were characterized by scanning electron microscopy (SEM). Changes in crystalline propertywere characterized by X-ray diffraction (XRD). Platelet adhesion tests of the modified PCL-b-PLLA filmsurfaces were evaluated by platelet-rich plasma (PRP) and whole blood. Cell adhesive behavior on themodified film surfaces was evaluated by fibroblast cell culture. The prepared lotus-leaf-like structuredfilm surfaces exhibited reduced platelet adhesion and an increased fibroblast cell proliferation ratio.
- URI
- http://pubs.kist.re.kr/handle/201004/48869
- ISSN
- 09277765
- Appears in Collections:
- KIST Publication > Article
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