Integrated microRNA-mRNA analysis for the role of habenula in mouse nicotine self-administration
- Integrated microRNA-mRNA analysis for the role of habenula in mouse nicotine self-administration
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- Numerous studies have suggested the role of microRNA(miRNA) in the neuroadaptions during drug addiction. Habenula in brain have been reported to be involved in the addiction of nicotine by regulating the reward circuit. However, integrated molecular mechanisms between miRNAs and mRNA within habenula are not elucidated. In this study, mouse nicotine self-administration via intravenous infusion of nicotine was executed. miRNA and mRNA expressions of habenula were analyzed via respective microarray and clustered by the change of expression among the nicotine-addicted mice and control mice. Several miRNAs and mRNAs were changed significantly by nicotine and some mRNAs were also designated as putative targets of miRNAs. GO (Gene Ontology) and KEGG (Kyoto Encyclopedia of Genes and Genomes) pathways analyses with mRNA showed that regulation of calcium signaling, neurotrophin signaling and neuroactive ligand-receptor interaction were involved with nicotine. Regulation of cell death and axonal outgrowth by miRNAs was especially involved in medial habenula. This study provides an improved insight about the role of the habenula in nicotine addiction model and the function of miRNAs in several biological pathways involved in the nicotine addiction.
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