PUFA related gene regulation of Coffee metabolites in liver and brain of mice with hypoxia-induced retinal degeneration
- PUFA related gene regulation of Coffee metabolites in liver and brain of mice with hypoxia-induced retinal degeneration
- 백지협; 김종민; 장호림; 정상훈; 박우정
- Issue Date
- 2014 한국식품영양과학회 국제심포지엄
- Coffee has been reported that it looks to reduce the risk of several chronic diseases such as Parkinson's, prostate cancer, and diabetes. Very recently it was reported that coffee metabolite positively affect on the health of eyes. Many epidemiological and clinical studies have suggested that consumption of DHA (Docosahexaenoic acid, 22:6n-3), a critical component in retina, has been important for eye health. FADS (Fatty acid desaturase) genes are located in human chromosome 11q13 and mammals including humans contain three desaturase genes in their chromosomes. FADS1 is known as a delta-5 desatuase, FADS2 is called delta-6 desaturase, and the function of FADS3 has not been known in LCPUFA regulation. Since the report of FADS3 alternative transcripts (AT), many of FADS AT have been reported and they were differentially expressed in diverse physiological conditions. However, no one reported the association between PUFA regulation and coffee metabolites on retinal degeneration. Our study show that the alternative transcripts of three FADS genes are regulated in liver and brain of mice with retinal degeneration depending on the exposure of coffee metabolites.
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