Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model
- Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model
- 박진우; 구숙희; 문형호; 이민형; 최동훈; 양재문; 허민용; 정지훈; 박태관; 목혜정; 김선화
- cell engineering; cerebral ischemia model; cross-linked iron oxide nanoparticles; magnetic resonance imaging; mesenchymal stem cells
- Issue Date
- Macromolecular bioscience
- VOL 14, NO 3, 380-389
- Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.