Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model

Title
Cross-linked Iron Oxide Nanoparticles for Therapeutic Engineering and in Vivo Monitoring of Mesenchymal Stem Cells in Cerebral Ischemia Model
Authors
박진우구숙희문형호이민형최동훈양재문허민용정지훈박태관목혜정김선화
Keywords
cell engineering; cerebral ischemia model; cross-linked iron oxide nanoparticles; magnetic resonance imaging; mesenchymal stem cells
Issue Date
2014-03
Publisher
Macromolecular bioscience
Citation
VOL 14, NO 3, 380-389
Abstract
Poly(ethylene glycol)-coated cross-linked iron oxide nanoparticles (PCIONs) are developed for therapeutic engineering of mesenchymal stem cells (MSCs) and their monitoring via magnetic resonance (MR) imaging at a time. PCIONs successfully combine with plasmid DNA (pDNA) via ionic interaction. Accordingly, PCION/pDNA complexes mediate superior translocations of vascular endothelial growth factor (VEGF) pDNA into intracellular regions of MSCs under external magnetic field, which significantly elevate production of VEGF from MSCs. Genetically engineered MSCs are also clearly visualized via MR imaging after administration to rat cerebrovascular ischemia models, which enable tracking of MSCs migration from injected sites to injured ischemic area.
URI
http://pubs.kist.re.kr/handle/201004/49007
ISSN
16165187
Appears in Collections:
KIST Publication > Article
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