Responses of Blood Metabolites and Proteins to Different Vitamin A Levels in Korean Native Steers

Title
Responses of Blood Metabolites and Proteins to Different Vitamin A Levels in Korean Native Steers
Authors
왕타오이경훈정우석진용쳉이상범이재성황진희임지나김민정최성호최만호이홍구
Keywords
Korean native steers; Metabolomic; Proteomic; Vitamin A
Issue Date
2014-11
Publisher
PAKISTAN VETERINARY JOURNAL
Citation
VOL 34, NO 4, 527-531
Abstract
This study was conducted to determine the correlation between vitamin A restriction and serum metabolites as well as global proteins expression. Forty-eight animals were randomly divided into three groups and given different vitamin A supplementation: High (4.8 IU/g feed), Medium (2.43 IU/g feed) and Low (1.14 IU/g feed). Blood was collected individually via the external jugular veins. Results showed that the concentrations of Ca, total cholesterol, cortisol and cortisone, and the activity of 11beta-hydroxysteroid dehydrogenase (11-HSD) type 2 varied among the groups. An up-regulated (hibernation protein 25) and four down-regulated proteins (gelsolin a, alpha-1-microglobulin/bikunin precursor, transthyretin, and complement factor B) were identified in a proteomics study. These data demonstrated that vitamin A deficiency had considerable effects on the serum levels of several metabolites and global proteins expression and these metabolites and proteins may be used as physiological markers in the study of adipogenic differentiation prevention by vitamin A.
URI
http://pubs.kist.re.kr/handle/201004/49011
ISSN
02538318
Appears in Collections:
KIST Publication > Article
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