Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors

Title
Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors
Authors
Kyungjoon ParkSukwoon SongIngie HongBeomjong Song김정연Sungmo ParkJunuk Lee송상호Bobae AnJihye Kim이창준Ki Soon ShinSukwoo ChoiSukwon Lee
Keywords
calcium-permeable AMPA receptors; synaptic depotentiation; fear conditioning; lateral amygdala; longterm depression
Issue Date
2014-08
Publisher
Frontiers in behavioral neuroscience
Citation
VOL 8, 269-1-269-8
Abstract
There is conflicting evidence regarding whether calcium-permeable receptors are removed during group I mGluR-mediated synaptic depression. In support of this hypothesis, AMPAR rectification, a correlative index of the synaptic expression of GluA2-lacking calcium–permeable AMPARs (CP-AMPARs), is known to decrease after the induction of several types of group I mGluR-mediated long-term depression (LTD), suggesting that a significant proportion of synaptic CP-AMPARs is removed during synaptic depression. We have previously demonstrated that fear conditioning-induced synaptic potentiation in the lateral amygdala is reversed by group 1 mGluR-mediated depotentiation. Here, we examined whether CP-AMPARs are removed by mGluR1-mediated depotentiation of fear conditioning-induced synaptic potentiation. The synaptic expression of CP-AMPARs was negligible before, increased significantly 12 h after, and returned to baseline 48 h after fear conditioning, as evidenced by the changes in the sensitivity of lateral amygdala synaptic responses to NASPM. Importantly, the sensitivity to NASPM was not altered after induction of depotentiation. Our findings, together with previous results, suggest that the removal of CP-AMPARs is not required for the depotentiation of fear conditioning-induced synaptic potentiation at lateral amygdala synapses.
URI
http://pubs.kist.re.kr/handle/201004/49065
ISSN
16625153
Appears in Collections:
KIST Publication > Article
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