Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors
- Group I mGluR-dependent depotentiation in the lateral amygdala does not require the removal of calcium-permeable AMPA receptors
- Kyungjoon Park; Sukwoon Song; Ingie Hong; Beomjong Song; 김정연; Sungmo Park; Junuk Lee; 송상호; Bobae An; Jihye Kim; 이창준; Ki Soon Shin; Sukwoo Choi; Sukwon Lee
- calcium-permeable AMPA receptors; synaptic depotentiation; fear conditioning; lateral amygdala; longterm
- Issue Date
- Frontiers in behavioral neuroscience
- VOL 8, 269-1-269-8
- There is conflicting evidence regarding whether calcium-permeable receptors are removed
during group I mGluR-mediated synaptic depression. In support of this hypothesis,
AMPAR rectification, a correlative index of the synaptic expression of GluA2-lacking
calcium–permeable AMPARs (CP-AMPARs), is known to decrease after the induction of
several types of group I mGluR-mediated long-term depression (LTD), suggesting that
a significant proportion of synaptic CP-AMPARs is removed during synaptic depression.
We have previously demonstrated that fear conditioning-induced synaptic potentiation
in the lateral amygdala is reversed by group 1 mGluR-mediated depotentiation. Here,
we examined whether CP-AMPARs are removed by mGluR1-mediated depotentiation of
fear conditioning-induced synaptic potentiation. The synaptic expression of CP-AMPARs
was negligible before, increased significantly 12 h after, and returned to baseline 48 h
after fear conditioning, as evidenced by the changes in the sensitivity of lateral amygdala
synaptic responses to NASPM. Importantly, the sensitivity to NASPM was not altered after
induction of depotentiation. Our findings, together with previous results, suggest that the
removal of CP-AMPARs is not required for the depotentiation of fear conditioning-induced
synaptic potentiation at lateral amygdala synapses.
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