Cortical topography of auditory steady-state response in mice using high density EEG
- Cortical topography of auditory steady-state response in mice using high density EEG
- 김태; 정영인하; C. LEE; E. HWANG; 송윤규; 최지현
- Issue Date
- SOCIETY FOR NEUROSCIENCE
- Gamma-band (30-80 Hz) oscillations (GBO) are an important mechanism for coordinating neural activity in cognitive function and sensory processing. Altered gamma oscillations have also been implicated in the pathophysiology of neuropsychiatric disorders such as schizophrenia, dementia and bipolar disorder. Steady-state responses to trains of periodic stimuli have been used to investigate oscillations in auditory, visual, and somatosensory modalities. Especially, auditory steady state responses (ASSR) have been used to study the development and alteration of
GBO in schizophrenia. However, cortical topography of ASSR is not fully understood yet. Therefore we sought to investigate it using the high density electroencephalogram (hdEEG) for mice. B6/129 mice (n=5) were implanted with a polyimide-based microarray for hdEEG and 2 tungsten electrodes (75μm) for local field potential (LFP) in the primary auditory cortex. Mice were place in a cage and exposed to 500 ms duration click trains (150 times) at various frequencies (2, 10, 20, 30, 40, and 50; 75dB) generated from a speaker mounted in the mouse cage while
they were awake and hdEEG and LFP were being recorded. The hdEEG records the most of the cortex including frontal, centro-parietal, occipital, and upper side of temporal cortex. Topographical analysis of hdEEG and LFP showed that anterior frontal, occipital, and auditory cortex showed a significant response to auditory clicks with the strongest response at 40Hz and 50Hz, whereas insignificant or weak response was observed by auditory stimulation at lower frequencies (2, 10, 20, and 30 Hz). Connectivity analyses are pending. Our results support that ASSR is a reliable and non-invasive methodology to examine EEG oscillations, especially GBO, and ASSR at gamma band was most prominent in anterior frontal, auditory, and occipital region, which warrants the further investigation of its functional relationship and clinica
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