Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging
- Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging
- 서영훈; 조민주; 정욱재; 장우동; Tymish Y. Ohulchanskyy; 이상엽; 최동훈; Paras N. Prasad; 김세훈
- Biosensors; Hypoxia; Imaging agents; Low-bandgap conjugated polymers; Nanoparticles
- Issue Date
- VOL 39, 225-233
- Photonic nanomaterials have found wide applications in theranostics. We introduce here a design of allorganic photonic nanoparticles, different from traditional ones, in which we utilize nanoblend of a lowbandgap p-conjugated polymer (LB-CP) and polystyrene as the photonic core, surrounded by an FDAapproved polymeric surfactant. This design provides capability for efficient deep tissue imaging using highly penetrating near-infrared (NIR) excitation and emission of LB-CP and also allows us to incorporate a NIR phosphorescent oxygen-sensitive dye in the core to serve as a dual-emissive probe for hypoxia imaging. These biophotonic nanoblend (BNB) particles (~20 nm in diameter) show facile blood circulation, efficient disease targeting and minimal liver filtration as well as sustained renal excretion in the intravenously administered mouse models, as noninvasively visualized by the NIR emission signals. In diseased mouse models, pathological tissue deoxygenation at hypoxic sites was successfully detected with ratiometric spectral information. We also show that our nanoformulation exhibits no apparenttoxicity, thus serving as a versatile biophotonics platform for diagnostic imaging.
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