Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging

Title
Low-bandgap biophotonic nanoblend: A platform for systemic disease targeting and functional imaging
Authors
서영훈조민주정욱재장우동Tymish Y. Ohulchanskyy이상엽최동훈Paras N. Prasad김세훈
Keywords
Biosensors; Hypoxia; Imaging agents; Low-bandgap conjugated polymers; Nanoparticles
Issue Date
2015-01
Publisher
Biomaterials
Citation
VOL 39, 225-233
Abstract
Photonic nanomaterials have found wide applications in theranostics. We introduce here a design of allorganic photonic nanoparticles, different from traditional ones, in which we utilize nanoblend of a lowbandgap p-conjugated polymer (LB-CP) and polystyrene as the photonic core, surrounded by an FDAapproved polymeric surfactant. This design provides capability for efficient deep tissue imaging using highly penetrating near-infrared (NIR) excitation and emission of LB-CP and also allows us to incorporate a NIR phosphorescent oxygen-sensitive dye in the core to serve as a dual-emissive probe for hypoxia imaging. These biophotonic nanoblend (BNB) particles (~20 nm in diameter) show facile blood circulation, efficient disease targeting and minimal liver filtration as well as sustained renal excretion in the intravenously administered mouse models, as noninvasively visualized by the NIR emission signals. In diseased mouse models, pathological tissue deoxygenation at hypoxic sites was successfully detected with ratiometric spectral information. We also show that our nanoformulation exhibits no apparenttoxicity, thus serving as a versatile biophotonics platform for diagnostic imaging.
URI
http://pubs.kist.re.kr/handle/201004/49123
ISSN
01429612
Appears in Collections:
KIST Publication > Article
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