Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy

Title
Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
Authors
Jo Hyoung정상훈Kang JunYim Hye BinKang Kui Dong
Keywords
Angiogenesis; MMP; Retinopathy; Sulodexide; VEGF
Issue Date
2014-11
Publisher
BMB REPORTS
Citation
VOL 47, NO 11, 637-642
Abstract
Sulodexide is a mixed glycosaminoglycan composed of heparin and dermatan sulfate. In this study, the anti-angiogenic effect of sulodexide was investigated using an oxygen-induced retinopathy (OIR) mouse model. The retinas of sham-injected OIR mice (P17) had a distinctive central area of nonperfusion, and this area was significantly decreased in sulodexide-injected mice. The number of neovascular tufts measured by SWIFT_NV and mean neovascular lumen number were significantly decreased in sulodexide-injected mice. Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed. Our results clearly demonstrate the anti-angiogenic effect of sulodexide and highlight sulodexide as a candidate supplementary substance to be used for the treatment of ocular pathologies that involve neovascularization.
URI
http://pubs.kist.re.kr/handle/201004/49175
ISSN
19766696
Appears in Collections:
KIST Publication > Article
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