Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
- Sulodexide inhibits retinal neovascularization in a mouse model of oxygen-induced retinopathy
- Jo Hyoung; 정상훈; Kang Jun; Yim Hye Bin; Kang Kui Dong
- Angiogenesis; MMP; Retinopathy; Sulodexide; VEGF
- Issue Date
- BMB REPORTS
- VOL 47, NO 11, 637-642
- Sulodexide is a mixed glycosaminoglycan composed of heparin and dermatan sulfate. In this study, the anti-angiogenic effect of sulodexide was investigated using an oxygen-induced
retinopathy (OIR) mouse model. The retinas of sham-injected OIR mice (P17) had a distinctive central area of nonperfusion, and this area was significantly decreased in sulodexide-injected
mice. The number of neovascular tufts measured by SWIFT_NV and mean neovascular lumen number were significantly decreased in sulodexide-injected mice. Hyperbaric oxygen exposure resulted in increased levels of VEGF, MMP-2 and MMP-9, and when mice were treated with sulodexide, a dose-dependent reduction in VEGF, MMP-2 and MMP-9 levels was observed. Our results clearly demonstrate the anti-angiogenic effect of sulodexide and highlight sulodexide as a
candidate supplementary substance to be used for the treatment of ocular pathologies that involve neovascularization.
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