The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells

Title
The synthesis of sulforaphane analogues and their protection effect against cisplatin induced cytotoxicity in kidney cells
Authors
김태정김영주한임호이다해함정엽강기성이재욱
Keywords
sulforaphane; Cisplatin induced kidney disease; Kidney protection; Reactive oxygen species; ROS; Isothiocyanate
Issue Date
2015-01
Publisher
Bioorganic & medicinal chemistry letters
Citation
VOL 25, NO 1, 62-66
Abstract
A series of sulforaphane analogues were synthesized with various amines by treatment of carbon disulfide followed by Boc2O and DMAP. These synthesized sulforaphane analogues were tested on cisplatin treated cultured LLC-PK1 kidney cell line. Among these analogues, several compounds including SF5 show a potent effect on kidney cell protection assay at the concentration of 2.5 μM. Further studies with compound SF5 revealed that the kidney cell protection effect was related by inhibiting the apoptosis pathway through JNK-p53-caspase apoptotic cascade. Compound SF5 may be considered as a promising candidate for the development of new kidney protection agent against drug induced acute kidney disease.
URI
http://pubs.kist.re.kr/handle/201004/49202
ISSN
0960894X
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE