The cytosolic splicing variant of NELL2 inhibits PKCb1 in glial cells
- The cytosolic splicing variant of NELL2 inhibits PKCb1 in glial cells
- 이다용; 김은주; 이영선; 유화니; 박재용; 황은미
- Issue Date
- Biochemical and biophysical research communications
- VOL 454, NO 3, 459-464
- NELL2 is an abundant glycoprotein containing EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytosolic NELL2 (cNELL2) which is non-secreted splicing variant of NELL2. Although cNELL2 structure was well characterized, the expression pattern or the cellular function of cNELL2 is not fully determined. In this study, we found that cNELL2 specifically interacts with PKCb isotypes and inhibits PKCb1 through direct binding to the N-terminal pseudosubstrate domain of PKCb1. Here, we also demonstrate that cNELL2 is predominantly expressed and has inhibitory effects on the PKC downstream signaling pathways in astrocytes thereby establishing cNELL2 as an endogenous inhibitor of PKCb1 in glia.
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