The cytosolic splicing variant of NELL2 inhibits PKCb1 in glial cells

Title
The cytosolic splicing variant of NELL2 inhibits PKCb1 in glial cells
Authors
이다용김은주이영선유화니박재용황은미
Issue Date
2014-10
Publisher
Biochemical and biophysical research communications
Citation
VOL 454, NO 3, 459-464
Abstract
NELL2 is an abundant glycoprotein containing EGF-like domain in the neural tissues where it has multiple physiological functions by interacting with protein kinase C (PKC). There are two different splicing variant forms of NELL2 identified so far. One is secreted NELL2 (sNELL2) which is a neuron-specific variant and the other is cytosolic NELL2 (cNELL2) which is non-secreted splicing variant of NELL2. Although cNELL2 structure was well characterized, the expression pattern or the cellular function of cNELL2 is not fully determined. In this study, we found that cNELL2 specifically interacts with PKCb isotypes and inhibits PKCb1 through direct binding to the N-terminal pseudosubstrate domain of PKCb1. Here, we also demonstrate that cNELL2 is predominantly expressed and has inhibitory effects on the PKC downstream signaling pathways in astrocytes thereby establishing cNELL2 as an endogenous inhibitor of PKCb1 in glia.
URI
http://pubs.kist.re.kr/handle/201004/49211
ISSN
0006291X
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