Capillary electrophoresis methods for microRNAs assays

Title
Capillary electrophoresis methods for microRNAs assays
Authors
반은미송은주
Keywords
capillary electrophoresis; laser-induced fluorescence; microRNA
Issue Date
2014-12
Publisher
Analytica chimica acta
Citation
VOL 852C, 1-7
Abstract
MicroRNAs (miRNAs) are short noncoding RNAs that conduct important roles in many cellular processes such as development, proliferation, differentiation, and apoptosis. In particular, circulating miRNAs have been proposed as biomarkers for cancer, diabetes, cardiovascular disease, and other illnesses. Therefore, determination of miRNA expression levels in various biofluids is important for the investigation of biological processes in health and disease and for discovering their potential as new biomarkers and drug targets. Capillary electrophoresis (CE) is emerging as a useful analytical tool for analyzing miRNA because of its simple sample preparation steps and efficient resolution of a diverse size range of compounds. In particular, CE with laser-induced fluorescence detection is a promising and relatively rapidly developing tool with the potential to provide high sensitivity and specificity in the analysis of miRNAs. This paper covers a short overview of the recent developments and applications of CE systems in miRNA studies in biological and biomedical areas.
URI
http://pubs.kist.re.kr/handle/201004/49277
ISSN
00032670
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KIST Publication > Article
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