Lysimachia vulgaris Attenuates Diet-Induced Obesity and Steatosis by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism cells

Title
Lysimachia vulgaris Attenuates Diet-Induced Obesity and Steatosis by Activating AMP-Activated Protein Kinase and Regulating Lipid Metabolism cells
Authors
김명석임수지안홍열정상훈노주원
Keywords
Lysimachia vulgaris; Obesity; Steatosis; AMP-Activated Protein Kinase
Issue Date
2015-01
Publisher
생화학분자생물학회 (KSBMB)
Abstract
The medicinal plant Lysimachia vulgaris has been reported to possess anti-oxidative and anti-inflammatory properties; however, its anti-obesity activity is unexplored. The present study was conducted to determine whether L. vulgaris extract (LVE), prepared from its rhizome parts, attenuated high-fat diet (HFD)-induced obesity in C57BL/6J mice. The molecular mechanism was investigated in HepG2 human hepatoma cells. LVE treatment decreased lipid and triglyceride accumulation in HepG2 hepatocytes by activating AMP-activated protein kinase (AMPK) signaling and regulating the expression of lipid metabolism-related proteins. In the animal model, oral administration of LVE (50 or 200 mg/kg/day for 8 weeks) significantly reduced HFD-induced body weight gain without altering the amount of food intake. Fat pad masses were reduced in LVE-treated mice, as evidenced by reduced adipocyte size. Furthermore, LVE protected against the development of nonalcoholic fatty liver by decreasing hepatic triglyceride accumulation. Taken together, these findings indicate that LVE attenuates HFD-induced obesity by activating AMPK and regulating lipid metabolism, suggesting a potent anti-obesity agent.
URI
http://pubs.kist.re.kr/handle/201004/49288
Appears in Collections:
KIST Publication > Conference Paper
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