Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells

Title
Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells
Authors
남은주이혜숙이영재주완석맹성호임혜인박찬웅김용식
Issue Date
2002-06
Publisher
The Korean Journal of Physiology & Pharmacology
Citation
VOL 6, 281-286
Abstract
To understand the cytotoxic mechanism of MPP+, we examined the involvement of ceramide in MPP+ -induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP+, MPP+ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to MPPMase) was exogenously added, and oleoylethanolamine (OE) was used to inhibit degradation of ceramide. Furthermore, inhibition of ceramide-activated protein phosphatase (CAPP), the effector of ceramide, using okadaic acid (OA) attenuated cell death but treatment of fumonisin B1, the ceramide synthase inhibitor, did not alter the cytotoxic effect of MPP
URI
http://pubs.kist.re.kr/handle/201004/49301
ISSN
12264512
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KIST Publication > Article
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