Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells
- Ceramide is Involved in MPP+ -induced Cytotoxicity in Human Neuroblastoma Cells
- 남은주; 이혜숙; 이영재; 주완석; 맹성호; 임혜인; 박찬웅; 김용식
- Issue Date
- The Korean Journal of Physiology & Pharmacology
- VOL 6, 281-286
- To understand the cytotoxic mechanism of MPP+, we examined the involvement of ceramide in MPP+ -induced cytotoxicity to human neuroblastoma SH-SY5Y cells. When SH-SY5Y cells were exposed to MPP+, MPP+ induced dose-dependent cytotoxicity accompanied by 2-fold elevation of intracellular ceramide levels in SH-SY5Y cells. Three methods were used to test the hypothesis that the elevated intracellular ceramide is related to MPPMase) was exogenously added, and oleoylethanolamine (OE) was used to inhibit degradation of ceramide. Furthermore, inhibition of ceramide-activated protein phosphatase (CAPP), the effector of ceramide, using okadaic acid (OA) attenuated cell death but treatment of fumonisin B1, the ceramide synthase inhibitor, did not alter the cytotoxic effect of MPP
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